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21KS-008
A systematic review of chronic postoperative opioid using bibliometric analysis
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Background: Chronic postoperative opioid use has become an important outcome in perioperative medicine. However, despite the recent surge of research regarding it, to the best of our knowledge, there has been only one systematic review published in 2019 in this field to date. Therefore, we aimed to analyze the research outputs of studies on this issue using bibliometric analysis.

Methods: Bibliometric analysis was performed by searching the Web of Science (WoS) database for chronic postoperative opioid use-related articles published between 2012 and 2020. Publication number, year, source, institution, country, and citation-related information were retrieved from the database. Only reviews and peer-reviewed articles written in English were included in the analysis. Two authors (HY Cho and SJ Lee) collected the following additional information independently through the review of the abstract: type of article (review, retrospective study, prospective observational study, and randomized controlled study), and type of surgery. If it was not possible to identify the aforementioned information from the abstract, the authors recorded that through the review of the full text. VOSviewer software (Leiden University, Leiden, Netherlands) was used for mapping and clustering of keywords. Descriptive statistics were conducted using the MedCalc Statistical Software version 18.6 (MedCalc Software bvba, Ostend, Belgium).

Results: A total of 410 publications were extracted from the database and 197 articles were finally included in the analysis. The total number of citations, average citation per item, and h-index of them was 4,380, 22.23 and 28, respectively. The most type of surgery in the original articles was orthopedic extremity surgery except spine surgery (n = 65, 39.9 %), followed by spine surgery (n = 29, 17.8 %). The country that published the most articles related to chronic postoperative opioid use was the United States (n = 171, 86.8 %), followed by the Australia (n = 16, 8.1 %). Of a total of 683 keywords, 66 were extracted and the most frequent keyword was risk factor (n = 97), followed by United-States (n = 53). A total of 149 articles have reported risk factors associated with chronic postoperative opioid use. The most reported risk factors were preoperative opioid use (n = 79, 53.0%), followed by preoperative psychologic problems (n = 54, 36.2%).

Conclusions: Our study revealed a recent rapid increasing trend in the number of publications regarding chronic postoperative opioid use, which indicates a growing interest in this field. This study provides valuable information regarding future studies.